James Stoll, Ph.D.

Reportable Conflicts of Interests:  None

Disclosure of Financial Conflicts of Interest: None

Education:
Doctor of Philosophy-Biochemistry
School of Hygiene and Public Health
The Johns Hopkins University
Baltimore, MD
Dissertation title: “Isolation and Characterization of CHO Glycosylation Mutants”

Bachelors of Science in Chemistry
New Mexico State University
Las Cruces, NM

 

Current Position or Practice Site:
Associate Professor
Texas tech School of Pharmacy
Amarillo, TX

Graduate Faculty
Graduate School of the Biomedical Sciences
Texas Tech University Health Science Center

Past Positions and/or Appointments:                       
Assistant Professor and Founding Faculty Member 1996-2003
Department of Pharmaceutical Sciences
Texas Tech School of Pharmacy
Amarillo, TX

Senior Staff Fellow 1990-1996
Laboratory of Neurosciences
National Institute on Aging
Bethesda, MD

Staff Fellow 1988-1989
Section of Genetic Studies
Laboratory of Clinical Studies
National Institute of Alcohol Abuse and Alcoholism
Bethesda, MD

National Research Council Associate 1986-1988
Section of Genetic Studies, Laboratory of Clinical Studies
National Institute on Alcohol Abuse and Alcoholism
Bethesda, MD

Research Assistant 1978-1980
Department of Chemistry
New Mexico State University
Las Cruces, NM

Professional Memberships:                                       
American Association for the Advancement of Science

American Chemical Society

American Society for Biochemistry and Molecular Biology

American Society for Neurochemistry

Society for Neuroscience

 

Publications:                                                       
Bennett KM, Hoelting C, Martin CP, Stoll J (2008) Estrogen effects on high-affinity choline uptake in primary cultures of rat basal forebrain. Neurochem Res. DOI 10.1007/s11064-008-9746-1

 

Bennett KM and Stoll J (2008) Expression and characterization of two novel transporter orthologs, BOCT1 and BOCT2.  2008 Experimental Biology Annual Meeting, Abstr. 813.4

 

Kiewert C, Hartmann J, Stoll J, Thekkumkara TJ, Van der Schyf CJ, Klein J (2006) NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels. Neurochem Res. 31:395-399.

 

Bennett K, Ngo L, Srader C, Stoll J  (2006) Characterization of two novel transporters, BOCT1 and BOCT2. 2006 Experimental Biology Annual Meeting, Abstr. 874.4

 

Bennett K, Hoelting C, Stoll J  (2005) Estrogen treatment and immunoselection of basal forebrain cholinergic neurons. J. Neurochem. 94 (Suppl. 1), O01-01

 

Bennett KM, Ngo L, Stoll J  (2005) Characterization of the low-affinity choline transporter and identification of two novel transporters, BOCT1 and BOCT2.  2005 Experimental Biology Annual Meeting, Abstr. 671.73

 

Ngo L, Stoll J. (2004) Characterization of a novel transporter, BOCT1. 7^th Annual Pharmacy Student Research Conference, Western Region, (Abstr II.15).

 

Stoll J, Hoelting C.  (2003) Is the low-affinity choline transporter a member of the organic cation transporter family: expression of OCT genes at the blood-brain barrier. Vth International Conference, Cerebral Vascular Biology 2003, (abstract)

 

Hoelting C, Stoll J.  (2003) Isolation and functional characterization of low affinity choline transporter in MC-IX-C neuroblastoma cells.  6^th Annual Pharmacy Student Research Conference Western Region, Abstr. IV.29

 

Stoll J, Hoelting C. (2003) The low affinity choline transporter is a member of the organic cation transporter family.  2003 Experimental Biology Annual Meeting, Abstr. 331.21

 

Stoll J, Martin C. and Hoelting C.  (2002) Estrogen effects on septal cholinergic neurons in culture. 31^st Annual Meeting of the American Aging Association, Abstr #37

 

Hoelting C. and Stoll J. (2002) Inhibition of choline uptake in MC-IX-C neuroblastoma cells by organic cations. 5^th Annual Pharmacy Student Research Conference Western Region  (Abstract IV.23)

 

Martin C, and Stoll J. (2002) The effects of phytoestrogens on the survival of basal forebrain cholinergic neurons in vitro. 5^th Annual Pharmacy Student Research Conference Western Region  (Abstract IV.21)

 

Galdzicki Z, Siarey R, Pearce R, Stoll J, and Rapoport SI. (2001) On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res. Rev. 35:115-145.

 

Shetty HU, Siarey RJ, Galdzicki Z, Stoll J, and Rapoport SI (2000) Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochem. Res. 25:431-435.

 

Stoll J, Nageshima T, Williams WM, Vannucci SJ, and Smith QR. (1999) Developmental regulation of the System y+ basic amino acid transporter at the rat blood-brain barrier. Soc. Neurosci. Abstr. 25, p1757.

 

Wheeler L, and Stoll J. (1999) Use of an RT-PCR method to quantify CAT-1 mRNA in rat brain endothelial cells.  (Abstract) Merck Pharmacy Undergraduate Research Seminar, June 1999

 

Stoll J, and Galdzicki Z. (1999) Alteration in cAMP production in hippocampal neurons cultured from the Trisomy 16 mouse (Abstr.) J.Neurochem. 72 (Suppl.), S36A

 

Chandrasekaran K, Hatanpaa K, Brady DR, Stoll J, and Rapoport SI. (1998) Downregulation of Oxidative Phosphorylation in Alzheimer Disease: Loss of Cytochrome Oxidase Subunit mRNA in the Hippocampus and Entorhinal Cortex. Brain Res. 796, 13-19.

 

Galdzicki Z, Coan EJ, Rapoport SI, and Stoll J.  (1998) Increased expression of voltage-activated calcium channels in cultured hippocampal neurons from mouse trisomy 16, a model for Down syndrome. Mol.Brain Res. 56, 200-206.

 

Siarey RJ, Stoll J, Rapoport SI, and Galdzicki Z.  (1997)  Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down’s syndrome. Neuropharmacology, 36, 1549-1554.

 

Stoll J. and Galdzicki Z. (1996) Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus. Int. J. Develop. Neurosci. 14, 749-760.

 

Hatanpaa K, Brady DR, Stoll J, Rapoport SI, and Chandrasekaran K. (1996) Neuronal activity and early neurofibrillary tangles in Alzheimer’s disease. Ann. Neurol. 40, 68-77.

 

Lane N, Balbo A, Stoll J, and Rapoport SI.  (1994)  Long term intracerebral transplants of hippocampus from mouse trisomy 16, a model for Down syndrome (trisomy 21), do not exhibit Alzheimer's disease neuropathology by ultrastructural criteria.  Tissue and Cell 26, 477-488.

 

Chandrasekaran K, Giordano T, Brady DR, Stoll J, Martin LJ, and Rapoport SI. (1994) Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Mol. Brain Res. 24, 336-340.

 

Stoll J, Wadhwani KC, and Smith QR. (1993) Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier.  J. Neurochem. 60, 1956-1959.

 

Stoll J, Balbo A, Ault B, Rapoport SI, and Fine A. (1993)  Long-term transplants of mouse trisomy 16 hippocampal neurons, a model for Down's syndrome, do not develop Alzheimer's disease neuropathology.  Brain Res.  610, 295-304.

 

Chandrasekaran K, Stoll J, Rapoport SI, and Brady DR.  (1993)  Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain.  Brain Res.  606, 213-219.

 

Stoll, J., Cacan, R., Verbert, A. and Krag, S.S. (1992) Lec15 cells transfer glucosylated oligosaccharides to protein. Arch. Biochem. Biophys.  299, 225-231.

 

Chandrasekaran, K., Stoll, J., Giordano, T., Atack, J.R., Matocha, M.F., Brady, D.R. and Rapoport, S.I. (1992) Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain  J. Neurosci. Res. 32, 415-423.

 

Chandrasekaran, K., Stoll, J., Brady, D.R. and Rapoport, S.I. (1992)  Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways. Brain Res. 579, 333-336.

 

Stoll, J. and Goldman, D. (1991) Isolation and structural characterization of the murine tryptophan hydroxylase gene. J. Neurosci. Res., 28,457-465.

 

Rosenwald, A.G., Stoll, J., and Krag, S.S. (1990) Regulation of glycosylation. Three enzymes compete for a common pool of dolichyl phosphate in vivo. J. Biol. Chem.  265, 14544-14553.

 

Stoll, J., Kozak, C.A. and Goldman. D.  (1990) Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line. Genomics, 7, 88-96.

 

Stoll, J. and Krag, S.S. (1988) A mutant of Chinese hamster ovary cells with a reduction in levels of dolichyl phosphate available for glycosylation. J. Biol. Chem. 263, 10766-10773.

                  

Stoll, J., Rosenwald, A.E., and Krag, S.S. (1988) A Chinese hamster ovary cell mutant F2A8 utilizes polyprenol rather than dolichol for its lipid-dependent asparagine-linked glycosylation reactions. J. Biol. Chem. 263, 10774-10780.

         

Stoll, J., Rosenberg, L., Carson, D.D., Lennarz, W.J., and Krag, S.S. (1985) A single enzyme catalyzes the synthesis of the mannosylphosphoryl derivatives of dolichol and retinol in rat liver and Chinese hamster ovary cells. J. Biol. Chem. 260, 232-246.

 

Stoll, J., Robbins, A.R., and Krag, S.S. (1982) Mutant of Chinese hamster ovary cells with altered mannose-6-phosphate receptor is unable to synthesize mannosylphosphoryldolichol. Proc. Natl. Acad. Sci. USA 79, 2296-2300.

         

Burnett, T.J., Stoll, J., and Hageman, J.H.. (1981) Hydrolysis of Carbobenzyloxy-L-Glutamyl-p-Nitroanilide and Carbobenzyloxy-L-Glutaminyl-p-Nitroanilide by Subtilisin BPN' and by extracts of Bacillus subtilis. Federation Proceedings 40, 1433a (abstract)

 

 

Books and/or Chapters:
Smith, Q.R. and Stoll,J.  (1999) “Molecular characterization of amino acid transporters at the blood-brain barrier” In Alfred Benzon Symposium 45, Blood Brain Barrier Systems, O. Paulsen, GM Knudsen, T Moos (eds), Munksgaard, Copenhagen, pp 303-317.

 

Smith, Q.R. and Stoll,J.  (1998) “Blood-brain barrier amino acid transport”. In An introduction to the Blood-brain barrier: methodology and biology, W.M.Pardridge (ed.), Cambridge Univ. Press, pp 188-197.

 

Stoll,J., Rosenwald,A.E. and Krag,S.S. (1990) “Mutants:  a fruitful approach to the understanding of asparagine-linked glycosylation in eukaryotic cells.”  In NATO ASI Series H, Vol. 40, Dynamics and Biogenesis of Membranes ,  J.A.F. Op den Kamp (ed.),  Springer-Verlag, Berlin, pp. 151-166.

 

(Last updated: 2/9/2009)