Issue 12: Question: Why should patients receiving cyclosporine (Gengraf, Neoral, Sandimmune) for the prevention of kidney organ transplantation rejection not take St. John's Wort (Hypericum perforatum)?
Issue 37: Question: What herbal or natural medicines are known to be inhibitors of cytochrome P450 (CYP) 3A4, thereby increasing the risk for causing clinically relevant drug interactions with many medications?
Issue 19: Question: What is the mechanism by which Cat's claw (Uncaria tomentosa) can increase the blood concentrations of the protease inhibitors, atazanavir (Reyataz®), ritonavir (Norvir®), saquinavir, (Invirase®) used for the treatment of HIV?
Issue 18: Question: What is the mechanism by which the homeopathic medicine, Oscillococcinum (Anas barbariae hepatis et cordis extractum 200CK HPUS) is proposed to prevent or treat influenza (flu) viral infections?
Issue 17: Question: Is there any evidence that the homeopathic medicine, Oscillococcinum (Anas barbariae hepatis et cordis extractum 200CK HPUS) is effective at preventing or treating swine-origin influenza A (H1N1) viral infections?
Issue 15: Question: What is the mechanism by which coenzyme Q10 supplementation treats statin (HMG-CoA reductase inhibitors) induced myopathy (myalgia (muscle pain), myositis (muscle breakdown) or rhabdomyolysis)?
Issue 14: Question: Part 2: If the primary mechanism for pain relief is not substance P depletion, as commonly thought, then what is the mechanism by which continued use of topical capsaicin results in pain relief and when does this relief normally begin?
Issue 13: Question: Part 1: What is the mechanism by which topical capsaicin initially causes pain (a burning or stinging type of feeling) and possibly mild redness and swelling when being used for chronic pain management?