Drug Interactions Newsletter

Volume 1, Issue 3, 02/04/2009

Question

Why should patients taking nitrates (nitroglycerin injection, tabs, patches or ointments) for their heart disease not receive type 5 phosphodiesterase inhibitors (Viagra, Cialis, or Levitra) for the treatment of erectile dysfunction (ED)?

Answer

Nitroglycerin, regardless of the dosage form, is converted to nitric oxide (NO) once in the body.  It is commonly used in the treatment of angina (chest pain) in patients with underlying ischemic heart disease (IHD).  Since IHD can result in decreased coronary blood perfusion to the heart, the use of nitroglycerin can help dilate these vessels to increase coronary perfusion, thus reducing the severity of angina......To read the full answer please LOGIN or SUBSCRIBE NOW.