Drug Interactions Newsletter

Volume 2, Issue 6, 02/09/2010

Question

What medications are known substrates for UDP-glucuronosyltransferase (UGT) 1A1 enzyme mediated drug interactions?

Answer

As it relates to metabolism of a medication, the CYP450 enzyme system is known to contribute the most for many medications.(1-3)  The second largest contributor occurs through the UGT enzymes.(3)  As it relates to the UGT enzymes, there are eleven different UGT enzyme subtypes that are currently known to contribute to the phase II metabolism of many medications used in clinical practice.  Of the eleven UGT enzymes...

The complete answer to this question comes with a table that summarizes the common medications that are known to be substrates of UGT1A1.

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