Drug Interactions Newsletter

Volume 3, Issue 10, 03/08/2011

Question

How does disulfiram (Antabuse) interact with alcohol (ethanol) to cause patients to get so sick?

Answer

Disulfiram (Antabuse) is an oral medication used to facilitate abstinence from alcohol in patients who remain in a state of enforced sobriety.  It works to motivate patients to avoid alcohol due to its effect on alcohol metabolism, which can cause unpleasant symptoms if alcohol is ingested.  These unpleasant symptoms include, but are not limited to...

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