Drug Interactions Newsletter

Volume 1, Issue 29, 08/04/2009

Question

Why is eplerenone (Inspra®) prone to more drug interactions than spironolactone (Aldactone®)?

Answer

Eplerenone (Inspra®) and spironolactone (Aldactone®) are both aldosterone antagonists that can be used for the treatment of hypertension (HTN) and heart failure (HF) due to left ventricular systolic dysfunction.(1,2)  In addition to these indications, spironolactone is also used in the management of primary hyperaldosteronism, edema from cirrhosis, and prophylaxis against hypokalemia.(2)   Additionally, spironolactone is available generically and is known to have fewer drug interactions than compared to eplerenone.  

The reason eplerenone is subject to additional drug interactions versus spironolactone have to do with the differences in their... 

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