Drug Interactions Newsletter

Volume 2, Issue 42, 11/02/2010

Question

How long after stopping St. John's wort (Hypericum perforatum) does the inductive effects on cytochrome P450 (CYP) 3A4 enzymes continue to last?

Answer

St. John's wort is an herb that is derived from the tops of the flowering parts of Hypericum perforatum L. and is known to have several active ingredients which include cyclopseudohypericin, hypericin, hyperforin, isohypericin, protohypericin, pseudohypericin and several other flavonoids.(1)  As it relates to these active ingredients, hyperforin is a substrate for the activation of the...

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