Drug Interactions Newsletter

Volume 1, Issue 46, 12/01/2009

Question

What is an inhibitory constant (Ki) and how does it relate to understanding drug interactions?

Answer

This is part 1 of 2 part series.  Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice.  They are also concepts built upon in many of the newsletters.  A thorough understanding of both the mechanism and the clinical application of a drug interaction provides the clinician with the greatest opportunity for identifying and determining the relevancy of a particular interaction.

If clinicians have not already started to encounter Ki's in the literature and product package inserts for medications, they will likely encounter them in the future.(1-3)  The Ki, in part, becomes important for helping to predict...

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