As it relates to the metabolism of a medication, the CYP450 enzyme system contributes the most, with CYP3A4 being the most common enzyme in the metabolism of many medications.(1-3)  The second largest contributor to drug metabolism occurs through UGT enzymes.(3)  As it relates to the UGT enzymes, there are eleven different UGT enzymes that are currently known to contribute to the phase II metabolism of many of the most prescribed medications in clinical practice.  Fortunately, the number and degree of significance of drug-drug interactions associated through the UGT enzymes are not as problematic when compared to those of the CYP450 enzyme system.(3)  Of the eleven UGT enzymes, UGT2B7 appears to contribute to the metabolism of the greatest number of medications that are substrates for this enzyme (see table).(3-12)  Upon an evaluation of the 200 most prescribed medications in 2002, UGT2B7 was used by...

The complete answer to this question comes with a table providing a list of medications that are substrates, inhibitors and inducers of UGT2B7.

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