Drug Interactions Newsletter

Volume 1, Issue 39, 10/13/2009

Question

What is the process to determine if medications are to be classified as weak, moderate or strong inhibitors of CYP3A4?

Answer

Periodically, the editorial board will release an issue related to explaining principles or terms that all clinicians should be familiar with as many times these will come up in clinical practice.  They are also concepts built upon in many of the newsletters. 

It is well known that the cytochrome (CYP) P450 enzyme system is involved in drug metabolism of many medications used in clinical practice and have been implicated in the causing clinically relevant drug-drug interactions.(1,2)  There are a number of CYP450 enzymes involved in mediating drug interactions and commonly include....