Drug Interactions Newsletter

Volume 3, Issue 26, 07/14/2011

Question

What are some common medications known to inhibit the activity of thiopurine methyltransferase (TPMT)?

Answer

Thiopurine methyltransferase (TPMT) is a non-cytochrome P450 enzyme that is most commonly known for its metabolism of azathioprine and/or mercaptopurine on the risks of bone marrow suppression or efficacy in treating inflammatory bowel disease (IBD).(1)  While these medications are linked to this enzyme, there are other medications of importance that can also be impacted by TPMT.  Some of the additional medication substrates of TPMT include...

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