Natural Medicines Newsletter

Volume 1, Issue 19, 05/28/2009

Question

What is the mechanism by which Cat's claw (Uncaria tomentosa) can increase the blood concentrations of the protease inhibitors, atazanavir (Reyataz®), ritonavir (Norvir®), saquinavir, (Invirase®) used for the treatment of HIV?

Answer

Cat's claw (Uncaria tomentosa) is a plant found in the Amazon River basin.(1)  It gets its name from the curved, hooked thorns present on the vine which resemble a cat's claw.(1)  It has been used for centuries in South America for conditions such as chronic inflammatory disorders, viral infections, arthritis, gastrointestinal illnesses and even as birth control.(1-4)  In addition, some patients may try to use Cat's claw to increase white blood cells (WBC).(5,6)  As such, HIV patients are likely to consider this option in the hopes of not only treating their HIV secondary to its antiviral claims, but may also be trying to improve their immune function.(1,7,8) 

A recent case report describing an HIV-positive female being treated with......To read the full answer please LOGIN or SUBSCRIBE NOW.

Other keywords found in this issue:  cytochrome, CYP450, P-glycoprotein, P-gp, serum concentrations, protease inhibitors, PI