Natural Medicines Newsletter

Volume 1, Issue 22, 06/18/2009

Question

What is the mechanism of action of St. John's wort (Hypericum perforatum) in the treatment of depression?

Answer

St. John's wort (Hypericum perforatum L.) has been used for centuries to treat a number of common ailments (such as neuralgia, sleep disorders, wound healing, and hemorrhoids), but it is best known for its use in the treatment of mild to moderate depression.(1)  As it relates to depression, its use is most common in Germany and other areas throughout Europe and is increasing in the United States.(2,3)  The data supporting the safety and efficacy has been questioned by some government agencies due to a significant degree of heterogeneity and inconsistencies among the clinical trials done.(3)  Other meta-analysis have also shown a minimal benefit of St. John's wort especially when compared to placebo.(4)   Regardless, it is clear from a historical perspective that some patients will benefit from St. John's wort for the treatment of mild or moderate depression.  What is the mechanism by which St. John's wort improves the symptoms of depression?

St. John's wort is known to have several active ingredients which include.....

There is a figure with this newsletter that helps to explain how St. John's wort works to treat depression.

......To read the full answer please LOGIN or SUBSCRIBE NOW.