Volume 1, Issue 33, 09/03/2009
Is St. John's wort (Hypericum perforatum L.) effective in the treatment of major depression?
St. John's wort (Hypericum perforatum L.) is derived from the tops of the flowering parts of Hypericum perforatum L. and is known to have several active ingredients, which include cyclopseudohypericin, hypericin, hyperforin, isohypericin, protohypericin, pseudohypericin and several other flavonoids.(1,2) While it has been used for centuries to treat a number of common ailments (such as neuralgia, sleep disorders, wound healing, and hemorrhoids), it is most commonly used for the treatment of mild to moderate depression.(3) As it relates to depression, its use is most common in Germany and other areas throughout Europe and its use in the United States is increasing.(1)
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