Volume 1, Issue 15, 04/30/2009
What is the mechanism by which coenzyme Q10 supplementation treats statin (HMG-CoA reductase inhibitors) induced myopathy (myalgia (muscle pain), myositis (muscle breakdown) or rhabdomyolysis)?
It is not uncommon for clinicians to hear from some of their patients that the use of statins or HMG-CoA reductase inhibitors is associated with myopathy. Statin-associated myopathy can include myalgia (muscle pains or aches) and myositis (muscle breakdown).(1,2) In addition, these conditions may or may not be accompanied by elevations in creatine kinase (CK), but when elevated is associated with muscle breakdown.(1,2) Assuming no other risk factors for myopathy are present, how do statins cause myopathy and is it a direct or indirect effect of the statin on the muscle?
Other keywords found in this issue: mevalonate, farnesyl pyrophosphate, geranylgeranyl pyrophosphate, glycolysis, cellular respiration, oxidative stress.
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