Volume 2, Issue 11, 03/16/2010
What common genetic polymorphisms to vitamin K 2,3-epoxide reductase complex 1 (VKORC1) are known to influence the pharmacologic properties of warfarin (Coumadin, Jantoven)?
Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice. They are also concepts built upon in many of the newsletter publications. A basic understanding of the pharmacogenetic terminology commonly used in the literature as well as in clinical practice is important for understanding why some medications may cause varying responses in different patients. This can have a significant impact on both the efficacy and safety of the intervention being implemented.
A good example of this can be seen with genetic polymorphisms of vitamin K 2,3-epoxide reductase complex 1 (VKORC1) gene expression. VKORC1 is a small transmembrane protein found in the endoplasmic reticulum primarily inside...
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