Pharmacogenetics Newsletter

Volume 2, Issue 3, 01/19/2010

Question

What are the common genetic polymorphisms to cytochrome P450 (CYP) 2C19 that could impact drug metabolism?

Answer

Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice.  They are also concepts built upon in many of the newsletters.  A thorough understanding of both the mechanism and the clinical application of a drug interaction provides the clinician with the greatest opportunity for identifying and determining the relevancy of a particular interaction.

The table below is a summary of the main genetic polymorphisms, the populations primarily affected, the specific genetic mutation and the impact of the mutation on its activity.(1-7)  It is evident that patients from three main geographic regions of the world could manifest the genetic polymorphism of cytochrome P450 (CYP) 2C19 and includes patients from...

There is a table that provides a summary of characteristics for each of the genetic polymorphisms to CYP2C19 available with this issue: