Volume 2, Issue 43, 11/10/2010
What are common genetic polymorphisms to cytochrome P450 (CYP) 2D6 that could impact drug metabolism?
Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice. They are also concepts built upon in many of the newsletters. A thorough understanding of both the mechanism and the clinical application of a drug interaction or how a side effect occurs provides the clinician with the greatest opportunity for identifying and determining the relevancy of a particular interaction or adverse drug event.
The table below is a summary of the main genetic polymorphisms, the populations primarily affected, the specific genetic mutation and the impact of the mutation on its activity.(1-18) Compared to some of the other cytochrome P450 (CYP) enzymes involved in drug metabolism, it is evident from the table that...
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