Volume 3, Issue 3, 01/18/2011
What common genetic polymorphisms of the CYP1A2 enzyme have the potential to influence drug efficacy and/or safety?
Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice. They are also concepts built upon in many of the newsletters. A thorough understanding of both the mechanism and the clinical application of a drug interaction or how a side effect occurs provides the clinician with the greatest opportunity for identifying and determining the relevancy of a particular interaction or adverse drug event.
The table below is a summary of the main genetic polymorphisms (or variations) of CYP1A2 and if known, the populations primarily affected, the specific genetic mutation and the impact of the mutation on its activity.(1-15) Compared to some of the other cytochrome P450 (CYP) enzymes involved in drug metabolism, it is evident from the table that there appear to be...
There is a figure with this newsletter that summarizes the main genetic polymorphism of CYP1A2....
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