Volume 2, Issue 19, 05/11/2010
What is the mechanism by which iron supplements can cause significant toxicity in patients with genetic polymorphisms to the HFE gene?
In the previous newsletter publication dedicated to the topic of pharmacogenetics, a review of the common genetic defects or polymorphisms associated with an increased risk for the development of hemochromatosis were summarized. This newsletter publication will focus on the mechanism involved in patients with Hereditary Hemochromatosis (HH; Type 1) that predisposes patients to increased or excessive iron absorption. In order to understand how these genetic defects can facilitate this adverse event, it is important to have a basic knowledge of the normal pathways for iron absorption from the gastrointestinal tract.
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