Pharmacogenetics Newsletter

Volume 3, Issue 47, 12/27/2011

Question

Can metoprolol lower the pulse effectively in patients who are known ultra-rapid metabolizers of CYP2D6?

Answer

Metoprolol (Lopressor) is a well-known beta-1 selective beta-blocker used most commonly for hypertension, rate control, and heart failure.  In relation to its pharmacokinetic profile, metoprolol is the most dependent on CYP2D6 enzyme for its metabolism.  In fact, it is known that about....

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