Volume 2, Issue 35, 09/15/2010
What are common genetic polymorphisms to thiopurine methyltransferase (TPMT) that could impact drug metabolism?
Periodically, the editorial board will release an issue that explains general principles or terms that all clinicians should be familiar with as they are frequently encountered in clinical practice. They are also concepts built upon in many of the newsletters. A thorough understanding of both the mechanism and the clinical application of a drug interaction or how a side effect occurs provides the clinician with the greatest opportunity for identifying and determining the relevancy of a particular interaction or adverse drug event.
Thiopurine methyltransferase (TPMT) enzymes are most commonly linked to the metabolism of azathioprine and/or mercaptopurine and risks of bone marrow suppression. While these two medications are linked to this enzyme, there are...
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