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Newsletter Issues
- Drug Interaction & Mechanisms: What is the mechanism by which cyclosporine (Gengraf®, Sandimmune®, Neoral®) increases ezetimibe (Zetia®) blood concentrations over 3-fold?
- Drug Interaction Mechanism: How does calcium carbonate reduce absorption (or bioavailability) of ciprofloxacin (Cipro®)
- Drug Interaction Mechanisms: Are there any drug interactions between histamine 2 receptor antagonists (H2RA) and clopidogrel (Plavix®) or impact on platelet inhibition?
- Drug Interaction Mechanisms: Are there any studies evaluating the efficacy of using H2RA and clopidogrel in patients with stents?
- Drug Interaction Mechanisms: Differences among proton pump inhibitors (PPI) in their ability to inhibit clopidogrel (Plavix®) activation through the cytochrome P450 (CYP) enzyme system?
- Drug Interaction Mechanisms: Dose reduction of digoxin (Digitek®; Lanoxin®) when used with amiodarone (Cordarone®)?
- Drug Interaction Mechanisms: Drug characteristics that increase likelihood for drug interactions in presence of inhibitor of metabolism?
- Drug Interaction Mechanisms: How NSAIDs increase the concentrations of methotrexate and risk of side effects
- Drug Interaction Mechanisms: Influx transporters involved in drug transport and locations in the body
- Drug Interaction Mechanisms: Medications classified as strong inhibitors of CYP3A4
- Drug Interaction Mechanisms: The mechanism for metronidazole (Flagyl®) inhibition of warfarin (Coumadin®; Jantoven®) and increases on the INR.
- Drug Interaction Mechanisms: What are common medications that rely upon breast cancer resistance protein (BCRP)-mediated efflux from the body?
- Drug Interaction Mechanisms: What are the common efflux transporters involved in drug transport and interactions?
- Drug Interaction Mechanisms: What data are available regarding clopidogrel's (Plavix®) efficacy on platelet inhibition when given with a proton pump inhibitor (PPI)?
- Drug Interaction Mechanisms: What is the mechanism for ezetimibe's (Zetia®) increases in cyclosporine (Gengraf®, Sandimmune®, Neoral®) concentrations?
- Drug Interaction Mechanisms: What is the specific mechanism by which aluminum hydroxide inhibits the absorption of levothyroxine (L-thyroxine, T4, Synthroid®)?
- Drug Interaction Mechanisms: What medications are substrates for UGT2B7 mediated drug interactions?
- Drug Interaction Mechanisms: What type of inhibition does clarithromycin (Biaxin®) have on CYP450 3A4?
- Drug Interaction Mechanisms: Which fibrate (fenofibrate or gemfibrozil) inhibits glucuronidation thereby increasing risk for drug interactions?
- Drug Interaction Mechanisms: Which UGT enzymes are most likely to be involved in drug metabolism and thus targets for drug interactions?
- Drug Interaction Mechanisms: Why are digoxin concentrations increased by amiodarone (Cordarone®) use?
- Drug Interaction Mechanisms: Why is eplerenone (Inspra®) prone to more drug interactions than spironolactone (Aldactone®)?
- Drug Interaction Mechanisms: Why is fluvastatin (Lescol®; Lescol XL®) considered to be safer to give with cyclosporine (Gengraf®, Neoral®, Sandimmune®) compared to other statins?
- Drug Interaction Mechanisms: Why is lovastatin (Mevacor®) contraindicated in HIV-infected patients taking protease inhibitor (PI) based antiretroviral therapy?
- Drug Interaction Mechanisms: Why should febuxostat (Uloric®) not be given to patients taking azathioprine (Azasan® or Imuran®)?
- Drug Interaction: Mechanism for how the protease inhibitor, atazanavir (Reyataz®) increases the statin rosuvastatin (Crestor®)
- Drug Interaction: What data are available related to the drug interaction between proton pump inhibitors (PPI) and clopidogrel (Plavix®) on cardiovascular (CV) related endpoints?
- Drug Interactions & Mechanisms: Proton pump inhibitors (PPI) descrease antiplatelet effect of clopidogrel (Plavix)
- Drug Interactions: How are drugs classified to be a weak, moderate, or strong inhibitor of CYP3A4?
- Drug Interactions: How can the use of proton pump inhibitors decrease the absorption of itraconazole?
- Drug Interactions: How common is serotonin syndrome with tramadol and SSRI drug interaction?
- Drug Interactions: How does cyclosporine (Neoral, Sandimmune) interaction with pravastatin (Pravachol)?
- Drug Interactions: How does paroxetine (Paxil®) cause a 6 to 8 fold increase in atomoxetine (Strattera®) concentrations?
- Drug Interactions: How does trimethoprim/sulfamethoxazole (Bactrim) increase the risk for bleeding in patients on warfarin (Coumadin, Jantoven)?
- Drug Interactions: How does valproic acid and interact with lamotrigine (Lamictal) to cause life threatening rash?
- Drug Interactions: Ibuprofen (Advil; Motrin) interaction with methotrexate (Rheumatrex; Trexall) and risk of toxicity
- Drug Interactions: Part 1: How does tramadol cause serotonin syndrome in patients on SSRI antidepressants?
- Drug Interactions: What are the mechanisms for drug interactions that all clinicians need to know?
- Drug Interactions: What other genetic and nongenetic factors that are known to interact with drug therapy that all clinicians should consider?
- Drug Interactions: Why is simvastatin (Zocor) contraindicated in HIV patients taking PIs but not NNRTIs?
- Drug Interactions: Why is there a need to understand drug interactions?
- Drug Interactions: Why should nitroglycerin not be given to patients taking Viagra, Cialis or Levitra?
- Drug Interations: How does allopurinol interact with azathioprine to cause reductions in WBCs?
- How can Chrysanthemum morifolium taken along with azathioprine potentially increase the risk for bone marrow toxicity?
- How does eplerenone cause less gynecomastia than spironolactone?
- Natural Medicines & Mechanisms: Any Evidence that Oscillococcinum can Prevent or Treat the Swine-origin Flu (H1N1) infection?
- Natural Medicines & Mechanisms: Herbal and Natural Medicines that are CYP3A4 Inhibitors and Cause Drug Interactions
- Natural Medicines & Mechanisms: How can Cat's claw increase the concentrations of protease inhibitors used in treatment of HIV?
- Natural Medicines & Mechanisms: How can Chrysanthemum morifolium taken along with azathioprine potentially increase the risk for bone marrow toxicity?
- Natural Medicines & Mechanisms: How coenzyme Q10 and statin induced myopathy or muscle pain
- Natural Medicines & Mechanisms: How does licorice (Glycyrrhiza glabra) cause edema
- Natural Medicines & Mechanisms: How does licorice (Glycyrrhiza glabra) increase blood pressure and risk for hypertension?
- Natural Medicines & Mechanisms: How kava (Piper methysticum) increases risk of CNS depression or coma with alprazolam (Xanax)?
- Natural Medicines & Mechanisms: Is kava (Piper methysticum) safe and effective for the prevention and/or treatment of general anxiety disorder (GAD)?
- Natural Medicines & Mechanisms: Mechanism of melatonin as antioxidant and prevention of free radical damage.
- Natural Medicines & Mechanisms: Melatonin supplementation treatment of antipsychotic induced tardive dyskinesia (TD)?
- Natural Medicines & Mechanisms: St. John's wort efficacy in the treatment of major depression?
- Natural Medicines & Mechanisms: Topical capsaicin mechanism for burning, swelling and redness
- Natural Medicines & Mechanisms: Topical capsaicin mechanism for reducing pain with continued use
- Natural Medicines & Mechanisms: What are the top 10 most common herbs or natural medicines used by patients?
- Natural Medicines & Mechanisms: What does it mean when a product label says USP?
- Natural Medicines & Mechanisms: What is a nutraceutical and what are some examples of products on the market?
- Natural Medicines & Mechanisms: What is the mechanism of action of St. John's wort (Hypericum perforatum L) in the treatment of depression.
- Natural Medicines & Mechanisms: Why patients should not take kava (Piper methysticum) and valerian (valerina officinalis) together?
- Natural Medicines & Mechanisms: Why patients with liver disease or cirrhosis not take kava extract (Piper methysticum)?
- Natural Medicines & Mechanisms: Why should Cats Claw (Uncaria tomentosa) be avoided during pregnancy?
- Natural Medicines & Pharmacology: Garlic's mechanism for lowering blood pressure in hypertension
- Natural Medicines: Are there any data to support that antioxidant supplements can reduce mortality?
- Natural Medicines: Are there any herbs derived from Australia that can function as a xanthine oxidase inhibitor for patients with hyperuricemia and gout?
- Natural Medicines: Do fish oil (omega-3 fatty acid) supplements have mercury (Hg) in them?
- Natural Medicines: What are some common herbal medicines used in the treatment of schizophrenia?
- Natural Medicines: What are the criteria for the FDA to take an herbal or natural medicine off the market in the United States of America (USA)?
- Natural Medicines: What herbal or natural medicines are known to have antiplatelet effects or increase the risk for bleeding?
- Natural Medicines: What herbal or natural medicines are known to influence the activity of warfarin (Coumadin®; Jantoven®) or causes changes in the INR?
- Natural Medicines: What is the mechanism of action by which Misai Kucing or Java Tea (Orthosiphon stamineus Benth) causes diuresis or act as a diuretic?
- Natural Medicines: What is the mechanism of action by which Misai Kucing or Java Tea (Orthosiphon stamineus Benth) decreases uric acid or treats gout?
- Natural Medicines: What is the mechanism of action of Oscillococcinum for treatment of influenza A viral infections?
- Natural Medicines: Which Chinese and Indian herbs or supplements are known to be inhibitors of xanthine oxidase (XO) and possibly useful for hyperuricemia or gout.
- Natural Medicines: Can vitamin A supplements improve eye sight? If so, how?
- Natural Medicines: How does Goat's Rue or French Lilac work to treat diabetes mellitus?
- Natural Medicines: How does saw palmetto work to treat BPH and is there evidence to prove it?
- Natural Medicines: How does St. John's Wort decrease HIV medications in the body and the loss of viral control?
- Natural Medicines: How does the herb valerian (Valeriana officinalis) work to treat insomnia?
- Natural Medicines: Is Milk Thistle protective against liver damage or failure and if so how does it work?
- Natural Medicines: Is the active form of Vitamin D needed to increase Ca absorption found in OTC supplements?
- Natural Medicines: Part 1: How does garlic lower blood pressure or treat hypertension?
- Natural Medicines: What omega-3 fatty acids are found in fish oil and how does this impact dosing?
- Natural Medicines: Why are natural and herbal medicines not regulated by the FDA?
- Natural Medicines: Why should healthcare providers learn the pharmacology of natural or herbal medicines?
- Pharmacogenetics & Mechanisms: How do genetic variations to VKORC1 influence the safety and efficacy of warfarin (Coumadin; Jantoven®)?
- Pharmacogenetics & Mechanisms: How do you interpret single nucleotide polymorphisms (SNPs) when reported in the medical literature?
- Pharmacogenetics & Mechanisms: Single nucleotide polymorphism (SNP) & impact on drug therapy
- Pharmacogenetics & Mechanisms: What influences do genetic polymorphisms of CYP2C19 have on clopidogrel (Plavix®) and cardiovascular disease CVD)?
- Pharmacogenetics: What are common genetic risk factors for developing clots when taking oral contraceptives?
- Pharmacogenetics: Factor V Leiden & risk for venous thrombosis with oral contraceptives (birth control pill)
- Pharmacogenetics: How do genetic polymorphisms result in significant neutropenia with irinotecan?
- Pharmacogenetics: How is warfarin influenced by genetic polymorphisms to CYP2C9 and is testing needed?
- Pharmacogenetics: What are good online pharmacogenetic resources for clinicians?
- Pharmacogenetics: What are some common lab tests or techniques used for determining genetic polymorphisms that can facilitate patient specific drug therapy?
- Pharmacogenetics: What is pharmacogenetics and why should healthcare providers begin understanding it?
- Pharmacogenetics: What is the genetic influence on abacavir (Ziagen) induced hypersensitivity reaction?
- Pharmacology Weekly's - Drug Interaction Mechanisms: What is the mechanism by which histamine-2 receptor antagonists (H2RA) decrease the absorption of iron (ferrous sulfate)?
- Pharmacology Weekly's - Drug Interaction Newsetter: What medications are substrates for UGT1A1 mediated drug interactions?
- Pharmacology Weekly's - Drug Interaction Newsletter: What does it mean for a drug to be a mechanism-based inhibitor of cytochrome P-450 (CYP) 3A4?
- Pharmacology Weekly's - Drug Interaction Newsletter: What is an inhibitory constant (Ki) and how does it relate to understanding drug interactions?
- Pharmacology Weekly's - Drug Interaction Newsletters: What is a [I]/Ki ratio and how does it relate to predicting drug interactions?
- Pharmacology Weekly's - Drug Interaction: Is there any evidence that determine the impact histamine-2 receptor antagonists (H2RA) have on oral iron replacement therapy?
- Pharmacology Weekly's - Drug Interactions Newsletter: Update: New information about the use of clopidogrel and proton pump inhibitors in patients who have undergone PCI?
- Pharmacology Weekly's - Drug Interactions Newsletter: Why is it important to consider several dosage reductions in a patient on stable doses of the oral anticoagulant, warfarin, when initiating amiodarone?
- Pharmacology Weekly's - Natural Medicines & Mechanisms: Indonesian Herbal and Natural Medicines that Inhibit the CYP2D6 enzyme.
- Pharmacology Weekly's - Natural Medicines Newsletter: What North American herbs or supplements are known to be inhibitors of xanthine oxidase and possibly useful for gout?
- Pharmacology Weekly's - Natural Medicines Newsletter: Which Vietnamese herbs or natural medicines are known to be inhibitors of xanthine oxidase (XO) and possibly used for hyperuricemia or gout?
- Pharmacology Weekly's - Natural Medicines Newsletter: Does the dose of estrogen increase risk for clotting or venous thromboembolism (VTE)?
- Pharmacology Weekly's - Natural Medicines Newsletter: What North American herbs or supplements are known to be inhibitors of xanthine oxidase (XO) and possibly useful for gout or hyperuricemia?
- Pharmacology Weekly's - Natural Medicines: Does the inhibition of platelet aggregation by fish oil supplements (omega-3 fatty acids; EPA, DHA, Lovaza) affect the patient's actual risk for bleeding?
- Pharmacology Weekly's - Natural Medicines: How do omega-3 fatty acids (EPA & DHA) potentially increase the risk for bleeding or affect platelet aggregation?
- Pharmacology Weekly's - Pharmacogenetics Newsletter: What are common genetic polymorphisms to CYP2C19 that could impact drug metabolism?
- Pharmacology Weekly's - Pharmacogenetics Newsletter: Why should patients of Asian descent receive HLA genetic testing before being prescribed carbamazepine (Carbatrol; Equetro; Tegretol)?
- Pharmacology Weekly's - Pharmacotherapy Newsletter: What is the incidence of statin (HMG-CoA reductase inhibitor) associated myopathy, myositis and rhabdomyolysis?
- Pharmacology Weekly's - Pharmacotherapy Newsletter: How do you identify and label statin (HMG Co-A reductase inhibitors) associated muscle aches and pains (or myopathy)?
- Pharmacology Weekly's - Pharmacotherapy Newsletter: Why can ezetimibe (Zetia) be dosed only once a day for its lipid lowery efficacy?
- Pharmacology Weekly's - Pharmacotherapy Newsletter: Why is fondaparinux an alternative antithrombotic that can be used in patients with HIT but not LWMH?
- Pharmacology Weekly's: Drug Interaction's Newsletter - HIV Medication Drug Reference Tool?
- Pharmacology Weekly's: Pharmacotherapy Newsletter - How does the capsaicin 8% patch (Qutenza) work differently from traditional topical capsaicin for the treatment of chronic pain?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Are there any differences in oral contraceptives and the risk for venous thrombosis (VTE)?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Carbidopa use with levodopa (L-Dopa) in treatment of Parkinson's disease (PD)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Data supporting statins (HMG-CoA Reductase inhibitors) in primary prevention of cardiovascular disease
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Detailed mechanism on how glucocorticoids cause demargination of WBC
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Does Pharmacology Weekly have any reference tools for clinicians on chemotherapy related toxicities?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How can the antiviral, oseltamivir (Tamiflu®) work to treat the swine flu?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How can the oral antiarrhythmic medication, amiodarone (Cordarone), cause hypothyroidism and is it relevant?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How do ACE inhibitors cause hyperkalemia and who is at risk?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How do fluoroquinolone antibiotics increase risk of seizures or epilepsy?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How do heparin (UFH) and low-molecular weight heparin (LMWH) cause heparin induced thrombocytopenia (HIT)?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How do oral contraceptive (birth control pill) increase the concentration of clotting factors and risk for VTE?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How does amiodarone (Cordarone®) cause hyperthyroidism and what are important monitoring and treatment parameters?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How does linezolid (Zyvox®) cause thrombocytopenia and is it clinically relevant?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How does meperidine (Demerol) cause seizures and who is at risk for this side effect or toxicity?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How haloperidol (Haldol®) causes or increases risk for tardive dyskinesia (TD)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How steroids or glucocorticoids (dexamethasone) increase white blood cell (WBC) counts.
- Pharmacology Weekly's: Pharmacotherapy Newsletter: How the antihistamine, diphenydramine (Benadryl®) causes xerostomia (dry mouth)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Mechanism of opioid agonist in pain transmission.
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Oseltamivir (Tamiflu®) efficacy administered greater than 48 hours after onset of flu-like symptoms from H1N1 virus.
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Part 1: How does the antibiotic tetracycline stain teeth?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Part 2: How does the antibiotic minocycline stain teeth differently from tetracycline?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Part 3: Can tetracycline or minocycline tooth stains be prevented or treated?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Statins for Secondary Prevention of Cardiovascular Disease (CVD)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What are the differences in the mechanisms of action between allopurinol (Zyloprim®, Aloprim®) and febuxostat (Uloric®) as it relates to gout?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What are the two main factors that all clinicians should factor into medication adherence?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is average increase in WBC count seen with starting steroids (glucocorticoids)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is pharmacoecology and how does it relate to clinical pharmacology?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is pharmacotherapy and why should all healthcare providers understand it?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is the difference between heparin associated thrombocytopenia (HAT) and heparin induced thrombocytopenia (HIT)?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is the exact mechanism of action of ezetimibe (Zetia®) on inhibition of cholesterol in the intestine?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is the mechanism by which low-molecular weight heparin (LMWH) cause less heparin induced thrombocytopenia (HIT) than regular heparin?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What is the mechanism by which metformin (Glucophage®) can improve the lipid profile beyond its glucose lowering properties in type 2 diabetes mellitus (DM)?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: What risk factors have been associated with causing or putting patients at risk for heparin induced thrombocytopenia (HIT) or reduction in platelets?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Which antiretroviral used for the treatment of HIV can cause a false positive for marijuana on a urine drug screen and why?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Which fluoroquinolone antibiotics are not indicated for treatment of UTI?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why can diabetics taking beta blockers still sweat during an hypoglycemic episode?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why do children less than 2 years of age need 4 doses of pneumococcal vaccine versus only 1 one in adults?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why do children need conjugated pneumococcal vaccine whereas adults do not need the pneumococcal vaccine to be conjugated?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why does imipenem require cilastatin whereas the other carbapenems do not for the prevention of inactivation by dehydropeptidase (DHP-1) in proximal renal tubule?
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why is enoxaparin (Lovenox®) dosed differently than dalteparin (Fragmin®)
- Pharmacology Weekly's: Pharmacotherapy Newsletter: Why is propranolol preferred in thyroid storm or thyrotoxicosis?
- Pharmacotherapy & Pharmacology Mechanisms: Time frame for increases in WBC (neutrophils) with glucocorticoid initiation.
- Pharmacotherapy: Does Pharmacology Weekly have any reference tools for clinicians for side effects related to monoclonal antibodies used to treat cancer?
- Pharmacotherapy: Does Pharmacology Weekly have any reference tools for clinicians for side effects related to tyrosine kinase inhibitors used to treat cancer?
- Pharmacotherapy: How does metformin work to lower fasting blood sugars without causing hypoglycemia?
- What common genetic polymorphisms to VKORC1 are known to influence warfarin (Coumadin; Jantoven)?
- What is the only NNRTI used in the treatment of HIV infection known to be an inhibitor of CYP3A4?
- Why should organ transplant patients on cyclosporine not take St. John's Wort (Hypericum perforatum)?
- Why should patients not take kava and valerian containing supplements at the same time, especially if a benzodiazepine is being used?
(Last updated: 2/9/2009)
